Nutrition & Bleeding Disorders

 

Eating healthy is easier said than done, especially for people who are managing a chronic condition like a bleeding disorder. The stress of trying to keep up with a busy schedule can often lead to overeating, eating on the run and/or poor food choices. In our hurry-up lifestyle, zipping to a fast-food restaurant is often more convenient and less expensive than preparing a home-cooked meal. But when we eat out for lunch or dinner we have a tendency to consume larger portions and foods with more calories than we would normally eat.

So how do these choices affect your health if you have hemophilia? Increased weight strains your joints and muscles, and can lead to further complications, including increased bleeds in susceptible joints. And during times of bleeds you are often more sedentary and not able to participate in appropriate exercise to burn those excess calories.

If you have a tendency to increase food consumption when you are inactive, this can add to the dilemma if you are already overweight or obese. The Centers for Disease Control and Prevention report teens and children with hemophilia are almost twice as likely to become overweight as the general population.

This means it’s more important than ever for patients with hemophilia to be eating a balanced diet and controlling portion size.

In addition, of particular concern is the predisposition of osteoarthritis (arthritis where there is loss of cartilage) in people with hemophilia after repeated episodes of bleeding into a joint.

Obesity causes and complicates osteoarthritis by increasing the mechanical stress on the cartilage within the joint. In fact, next to aging, obesity is the most powerful risk factor for osteoarthritis of the knees.

Gentle exercise usually does not aggravate osteoarthritis when it’s done at a level that does not cause joint pain.

And if those problems aren’t enough for people with bleeding disorders, the complications associated with obesity alone are serious.

According to the World Health Organization, there are 300 million obese adults worldwide and 18 million children are classified as overweight.

Obesity causes more that 300,000 potentially avoidable deaths each year. It contributes to heart disease, osteoarthritis, diabetes, stroke, hypertension, cancer and sleep apnea.

So what can you do to ensure that you are as healthy as you can be?

Exercise and proper nutrition must be incorporated into a healthy lifestyle plan in order for you to maintain a healthy weight.

Improving your nutrition and physical exercise program should begin with a visit to your physician to make sure you are able to endure physical activity with no health risks. Appropriate exercise should then be performed. Thirty minutes of exercise daily is recommended to maintain weight; 60 minutes per day to lose weight.

Gradual changes in eating habits, such as the ones mentioned here, are most likely to yield long-term results:

Be aware of portion sizes, read labels and avoid snack foods. Steer clear of foods that are high in fat and calories and offer little in the way of nutritional value. Be mindful of “hidden” or overlooked sources of excess calories, such as large glasses of juice and soft drinks.

Increase your consumption of fruits and vegetables. Dark, leafy greens and orange fruits and vegetables are excellent sources of vitamins and minerals. They are also a rich source of fiber, which helps you to “fill up” and maintain intestinal health.

Try to eat at least half of your grains from whole grain products. Try oats, barley, whole wheat, flax seed, bran, brown rice and pasta. Whole grains help to satiate the appetite, lower cholesterol and stabilize blood glucose levels to avoid an afternoon “slump.” Eat baked snack items instead of fried.

Use low-fat dairy sources such as 1% or skim milk and low-fat cheeses. These contain plenty of vitamins and minerals without the fats that have been linked to heart disease. (If you cannot consume milk, look for other sources of calcium, such as calcium-fortified orange juice.)

Bake, broil or grill lean meats, poultry and fish. Avoid heavy gravies, sauces and toppings that are often full of calories from fat. Include some meatless meals during the week by incorporating dried beans, nuts and seeds into your menus. Dried beans provide an excellent source of protein, and are high in fiber and low in fat, with no cholesterol. (Cholesterol is found only in animal-derived food sources, such as meats, eggs and milk.)

Reduce fat intake and increase the use of “good fats.” These include olive and canola oils. Limit the use of butter, stick margarine, shortening and lard.

A few other nutritional suggestions are especially important for people with hemophilia.

In addition to maintaining healthy weight, people with bleeding disorders need to maintain normal blood volume and blood cell production. There are several nutrients involved in blood cell production, such as: iron, protein, copper, vitamin C, vitamin B12, vitamin B6, vitamin E and folic acid.

But it would be wise for patients to avoid vitamin E supplements since they may increase the risk of bleeding. A diet that incorporates all of the food groups should provide nutrients adequately.

During a bleed, it is estimated that a miniscule amount of iron—roughly .75 micrograms—is lost with each tablespoon (15 ml) of blood. Maintain your iron levels by eating naturally iron-rich foods such as liver, lean red meat and poultry, all of which provide the best and most readily absorbed iron sources.

Other excellent sources of iron are leafy green vegetables, broccoli, dried beans, grains and raisins. Combining iron-rich foods with good sources of vitamin C (such as orange juice) can enhance iron absorption.

Being realistic, you know that you’re not going to make perfect choices at every meal, but it is important to make the effort to try to improve your diet.

It’s OK to indulge in a piece of cake at a birthday party, but don’t forget to eat lots of fresh vegetables at the next meal.

In other words, “Spend your calories as wisely as you would your money.”

Editor’s Note: Jennifer LaFranco is director of clinical programs at The Mary M. Gooley Hemophilia Center in Rochester, New York. Diane Delorm is the consulting clinical dietitian at the center.

Hemophilia

Hemophilia is described as an inherited disease wherein blood clot formation does not occur appropriately. The term hemophilia has been derived from the Greek expressions ‘haima' denoting blood and ‘philia' referring to friend. People who have hemophilia are called hemophiliacs and they suffer from insufficiency of a protein known as clotting factor that acts with platelets to prevent bleeding at the place of an injury. In fact, following an injury, hemophiliacs are inclined to bleed for prolonged periods and they are more vulnerable to internal bleeding.

In other words, hemophilia may be called a disorder in formation of blood clots. Usually, when an individual suffers an injury, the blood begins to clot within a few minutes and this helps in repairing the wound. However, this is not the case with people having hemophilia because one of the major elements required for blood clot formation does not function correctly in their system. This insufficiency in the actions of this vital element necessary for blood clot formation may be absolute or only limited. People who have a complete deficiency of this ingredient in the blood are known to be suffering from severe cases of hemophilia.
However, even in cases of severe hemophilia, blood clot formation does not stop totally, but the process is very slow compared to normal conditions. The consequence of this is formation of flaky or fragile blood clots that are unable to endure the force of blood outflow. In addition, in such situations the tissues of the body get disturbed and the injury does not nurse appropriately. In case of severe or acute hemophilia most of the bleeding occurs internally - usually into the joints and the muscles. However, present treatment of hemophilia is very advanced and if it is initiated early enough there is no reason why the medical condition would persist or cause any hindrance in the patient's routine life.

Precisely speaking there are several ingredients involved in the process of blood clotting and the majority of them comprise proteins. We generally take these ingredients regularly through our food to ensure that our body is ready to react whenever there is any injury. Since we take these ingredients everyday, in the normal process the fresh elements are produced and supplied to the bloodstream, while the older elements die and are reprocessed or are get rid of by the body. In normal conditions, the intensity of the active ingredients in the bloodstream is quite low. However, as soon as there is any injury, it sets off a rise in production of these ingredients, which are then carried by the blood to the place where they are required for forming blood clots. Once they are delivered to the requisite sites, these ingredients immediately start restraining the harm and, at the same time, initiate the process to heal the wound.
It may be mentioned here that majority of the elements involved in the formation of blood clots are known as factors. In all, there are 12 such factors. One of these major ingredients is known as factor VIII, while another is called factor IX. When the body is unable to manufacture the usual factor VIII or the regular factor IX, it leads to the medical condition called hemophilia. In the instance when the factor VIII is abnormal (not normal), the medical condition is known as hemophilia A. Similarly, when the factor IX is not normal, the disorder is known as hemophilia B.

Between the two types of disorders, hemophilia A is more common - in fact, it is five times more prevalent compared to hemophilia B. Hemophilia A is also known as a deficiency of factor VIII, classical hemophilia or at times simply as ‘hemophilia'. Hemophilia can often be hazardous during treatment as factor VIII does not serve any purpose for an individual who also has hemophilia B. On the other hand, hemophilia B is denoted as a deficiency of factor IX and in the United Kingdom, where the disease was first diagnosed in a patient, it is particularly known as Christmas disease because the name of the person was Christmas.
Similar to the factors VIII and IX, all other ingredients or elements involved in the process of blood clot formation are categorized as Roman numerical, according to an international agreement.

Acuteness

In situations where all the ingredients or factors responsible for blood clot formation are anomalous or abnormal, the disorder or hemophilia is said to be acute or severe. On the contrary, instances when only a number of the factors are abnormal, the disorder or hemophilia is said to be of modest nature or of gentle harshness. Speaking in the terminology of numerals, an individual suffering from severe or acute hemophilia A possesses an intensity of factor VIII in his or her blood of zero international units. In other words, the patient has zero per cent intensity where the mean is normal. An individual with gentle hemophilia A possesses more than 0.05 international units in each milliliter of blood.

Being aware of the level or intensity of the affected factor or ingredient responsible for blood clot formation is imperative for at least three causes, including:

• Usually, but not for all time, the level or intensity points to what a patient may anticipate vis-à-vis physical problems.
• In addition, the level of the ingredient also specifies the type of treatment that is expected to be successful in a particular patient.
• In fact, the level is common in all members of the same family. Hence, an infant born in a family having a medical history of mild hemophilia will also inherit mild hemophilia.

Heritance

It is important to note that hemophilia is a medical condition that is hereditary. This denotes that the disease is bequeathed from one generation to another in a family having a history of this medical condition. The orders for producing the proteins like factors VIII and IX that are involved in the process of blood clotting are known as genes. In fact, all such genes jointly comprise the outline of an individual's life as well as his or her uniqueness. In all the human body contains as many as 100,000 genes that are together known as genome.
Any newborn inherits one half of his or her genome from their father and the other half from their mother. In fact, the genes are transmitted through the infant's father's sperm and the mother's egg into the chromosomes, structures inside the newborn's body known as chromosomes. During the fusion of the sperm and the egg at the time of conception actually determines the design of an individual's future right at the time of fertilization of the egg.
Precisely, humans possess 46 chromosomes in pairs. Of these 46 chromosomes, two establish the gender of any individual. These chromosomes are called X and Y. An individual receiving two X chromosomes (i.e., XX) will be a female, while anyone getting an X and a Y chromosome (i.e., XY) will be born as a male. As the genes for hemophilia A and B are present on an X chromosome, they are known to be linked with gender chromosomes.
Women receive two directives for manufacturing the factors VIII and IX - ingredients involved in the blood clot formation process, as their genes comprise two X chromosomes (XX). This has a definite advantage, as when one set of instruction is not working; the other set gets ready to fulfill the discrepancy. In such cases, the inactive anomalous or abnormal gene in women is covered up by the usual actions of the additional gene present in the next X chromosome. This is said to be the main reason for women usually not having hemophilia. Any individual possessing such an abnormal or anomalous gene is known as a carrier of the disease. In fact, they are called carriers because they carry the abnormal gene and subsequently contaminate their kids with the faulty gene. It is an extremely exceptional case when a woman may receive two abnormal factor VIII, factor IX or genes from her parents and have hemophilia. However, such exceptional cases are possible only when an individual with hemophilia copulates with a person who is a carrier of the medical condition.
In fact, there is an equal possibility of the carriers infecting their sons and daughters with hemophilia. In fact, the chances of this taking place are 50:50. Here are some possibilities when a carrier of the disease mates with anyone having hemophilia:

• The newborn baby will not become an heir to the hemophilia gene if the X chromosome along with the regular gene is inside a fertilized egg.
• However, a newborn will receive the hemophilia gene from his or her parents if the X chromosome along with an abnormal gene is present in the fertilized egg.
• If the newborn is a female, like her mother, she too will also become a carrier of hemophilia. If the newborn is a male, he will have hemophilia, as the Y chromosome in his gene does not posses any spare set of instructions for producing factor VIII or factor IX that work to facilitate the blood formation process.

A male, whose gender chromosomes comprise an X and a Y, with hemophilia may fertilize an egg (essentially an X chromosome) with a sperm that may contain an X chromosome or a Y chromosome. When his X chromosome fertilizes an egg, it results in the formation of a pair of X chromosomes (XX) denoting that the child will be a female. Since the X chromosome of the father contains abnormal genes, it is natural that all his daughters will be carriers of hemophilia. However, if the Y chromosome of the male fertilizes an egg, it will result in a pair of XY chromosomes, denoting that the child will be a male. Again, since the Y chromosome of the father is normal, it is expected that all his sons will also be normal. As these sons are unable to inherit hemophilia from their parents, they are also not in a position to transmit the disease to any of their respective offspring. In such cases, the streak of inheritance of the medical condition comes to an end and henceforth, these sons as well as their offspring will all be normal people without the disease.
It may be mentioned here that almost 33 per cent of the entire genetic chaos appear to be happening all of a sudden. In fact, in most cases family history regarding the generic disorders are absent. The reason behind this is the fact that the composition of our genes goes through alterations at times and any one of these modifications is able to cause hemophilia. Such changes in the genetic composition are known as mutations. Barring rare expert examinations, it is actually very difficult to determine the precise time of such mutations in any individual having a family history of hemophilia. As far as the timing of the mutations are concerned, there are numerous possibilities - a mutation may have taken place in the immediate past or it may have happened several generations before and it has been naively bequeathed down the female linage. And when is done, the default X chromosome that receives instructions to make factor VIII or factor IX that are involved in the process of blood clot formation are covered up by the actions of the normal X chromosomes. It may be noted that the females have a pair of X chromosomes that comprise their gender gene.

When treatment is essential

In the instance of your child being diagnosed of suffering from hemophilia it will take some time to adjust yourself with the situation and living with the child. Every time you are likely to be plagued with the worry that your child has hemophilia. In such cases, it will be difficult to think of anything else, but the fact that the child's future will be disturbed and difficult and also be troublesome for the family. However, there is unlikely to be any horrible bleedings during the childhood. Hence, you and your child will have sufficient time to educate yourselves regarding the manner in which you can deal with the routine raps and bruising before more serious bleedings commence.
Diagnosis of this medical condition may be done from the cord blood or in the newborn baby followed by several silent months during which hemophilia will result in only a few, if they are any, noticeable symptoms. As the mobility of a child having severe or acute hemophilia increases, he or she will be more prone to injuries and bruises. Though the injuries may appear to be nasty, they actually do not hurt them and until there is a massive collision, these bruises are more or less artificial or just skin deep. If they try to move their fingers over these bruises, they are likely to feel small lumps that may be shifted effortlessly above the tissues lying beneath. If this can be done, there is no requirement for any remedy. However, if you are unable to do this, look for instant medical assistance. If you have any permanent bruise, it is an indication of the fact that there is profuse bleeding deep inside the tissues and this will almost certainly require treatment.
In such cases, the bleeding occurs very close to the joints and unless the problem is insignificant, people having some understanding of hemophilia ought to inspect the problem. Although bleeding into the joints resulting in the bulge and inflammation of the joints are not likely till the age of two years, they may still happen at times in children below this age. However, if such symptoms do take place, it is essential to get treatment as early as possible as this will help to prevent any enduring harm. This is the primary reason why some physicians have been advising regular injections of prophylaxis, in which factors VIII and IX are administered to children above the age of two years and having severe hemophilia.
Besides bleeding into the joints or deep muscles, it is essential to seek the physicians' advice on what needs to be done in the case of head injuries. It is natural that all toddlers will trip and knock their heads. In such situations, it will be actually very tricky to determine if an injured head requires to be examined or not.

Tests and vaccinations

A number of tests may be conducted on a newborn to ascertain whether he or she is having hemophilia. Examinations, such as Guthrie test for phenyl-ketonuria, usually entail obtaining a small sample of blood by pricking the heel of the baby. In fact, the prick only injures the baby temporarily and does not cause any damage to a newborn inheriting hemophilia. It is important to note that, barring an urgent situation, never should any healthcare provider obtain blood sample from a newborn from a blood vessel close to his or her neckline (a peripheral jugular vein) or the fold or hollow on either side of the front of the body where the thigh joins the abdomen or the groin (femoral vein) with a view to diagnose whether the child has hemophilia or not. As these blood vessels are comparatively big, pricking around them may prove to be quite unsafe. In case it is essential to obtain blood samples from the veins close to the neckline or the groin, it is essential to keep a pressure on the spot for a minimum of five minutes and subsequently examine the place frequently for a number of hours. In the event of any troublesome swelling at the site, you need to put more pressure and this may also require some out of the ordinary healing.
In case the healthcare professionals fail to make a diagnosis from the blood sample obtained from the umbilical cord, it is advisable to wait till a prominent vein is formed and located in the wrist, hand, fold of the elbow or above of the foot of the newborn. The fact remains that as babies start growing and have mobility, the veins begin to appear better. In fact, it is comparatively not tricky to entrée any of the secondary veins before a baby is ten months old unless he is extraordinarily fat.
In addition, children with bleeding disorders should get the recommended vaccinations for their age group. The injections used to immunize are small in quantity and if inoculators maintain the pressure of their fingers at the spot of the shot for a minimum of five minutes, it is unlikely to result in any troublesome bleeding. It is important to note that besides inoculation all other types of intramuscular injections are prohibited in patients suffering from hemophilia. In such cases, medications may be administered through alternative methods, generally into a vein. The primary reason behind this is simple. In most cases, particularly antibiotics are generally quite huge in quantity and are able to stimulate far-reaching bleeding into the muscles without any doubt.

Healing

Treatment of hemophilia has become trouble-free these days. This is especially true for the developed nations where it is easy to get excellent blood products. Precisely speaking, treatment of hemophilia involves reinstating the absence of blood clotting actions of factor VIII or IX.
In the instance of people enduring hemophilia A, the replacement of the missing clotting activities of factor VIII or IX may be done by making use of a product prepared from blood plasma supplied by human donors or, sometimes, by pigs. Another way to do this is to use a factor VIII formulation prepared artificially by means of bioengineering. Whatever may be the product that is used to treat hemophilia, it is essential that they should go through strict examinations and steps are taken to eliminate any possible viral infection. In the case of hemophilia B, the formulation will possibly be a factor IX distillate prepared from human plasma.
Since all such condensed varieties of factors VIII and IX are quite costly, they need to be used judiciously. All such formulations are highly effectual in treating hemophilia and their launch in the market has virtually transformed the management and cure of this medical condition. During the period when these expensive formulations were not obtainable in great amounts, hemophilia treatment was done with unprocessed blood plasma in the formula of fresh frozen plasma or cryoprecipitate (a precipitate of factor VIII that is formed by cooling blood plasma). It was essential to store both these products in deep freeze. While these plain products are highly effectual in treating hemophilia, they are not very safe vis-à-vis viral contagions. In addition, it is more difficult to store as well as administer these simple products. Comparatively, the latest formulations for hemophilia treatment are expensive, but safer and also easier to administer.

Supplements and herbs

It is important that physicians use traditional or predictable medications to treat hemophilia. If you are suffering from hemophilia, always ask for immediate medical aid whenever you experience bleeding or pain and swelling at the joints. Nevertheless, there are a few CAM therapies that are likely to be effective when they are used in combination with traditional medications for specific symptoms of hemophilia. For instance, emotional and mental strain often influences the amount of bleeding. In fact, there are a few mind-body treatments that may be effective in alleviating pressure and nervousness. Findings of a number of researches have also hinted that hypnosis may perhaps lessen and not totally do away with the requirement for blood transfusions.
However, thus far there has been no research that has scrutinized the worth of herbs in particularly treating hemophilia and hence, it is not advisable to utilize herbal remedies without consulting a physician or without their direction. Nevertheless, depending on their individual experiences, some physicians or healthcare providers may suggest certain herbs that fortify the blood vessels as well as work as astringents to lessen the severity of the bleeding. These astringents actually help to cause contraction of the blood vessels.
Some of the herbs that your healthcare providers may recommend in the treatment of hemophilia may include:

• Hawthorn berry (Crataegus monogyna)
• Bilberry fruit (Vaccinium myrtillus)
• Scotch broom (Cytisus scoparius)
• Grape seed extract (Vitis vinifera)
• Yarrow (Achillea millefolium)
• Stinging nettle (Urtica dioica)
• Witch hazel (Hamamelis virginiana)

While the above-mentioned herbs may be useful for hemophilia patients, there are a number of herbs that they should avoid, as using these herbs will only increase the severity of bleeding. Some of the herbs that need to be avoided by hemophilia patients are as follows:

• Garlic (Allium sativum)
• Ginko (Ginko biloba)
• Ginseng (Panax spp.)
• Ginger (Zingiber officinale)
• Turmeric (Curcuma longa)
• Horse chestnut (Aesculus hippocastanum)

Homeopathy

Precisely speaking, there have been very few studies to examine the effectuality of homeopathic medications to treat hemophilia. Nevertheless, a number of reports have stated that using homeopathic remedies for hemophilia treatment have not only proved to be helpful for patients suffering from this condition, but also diminished their requirement for substances aiding blood clotting, such as factor VIII. It may be mentioned here that prior to prescribing a remedy, the homeopath practitioners take into consideration a patient's disposition - the physical, intellectual as well as emotional composition. Before deciding on the best suitable medication for a particular patient, a veteran homeopath practitioner will always take these aspects into consideration and evaluate them minutely along with any symptoms present in the patient.
The homeopathic medications that have been found to be effective in treating hemophilia in certain cases are as follows:

• Arnica
  This homeopathic remedy may be used for bleeding both internally as well as externally soon after an injury. This medication is also effective for treating trauma and shock.
• Carbo vegetabilis
  This medication is useful for people having pale skin, weakness and very feeble. It can be administered to people who are also lethargic.
• Crotalus horridus
  This homeopathic medication is administered in the case of bleeding into the muscles as well as in cases where the blood seems watery and gloomy. The medication is especially suitable for people who are tall, slender and pale suffering from diarrhea and have a dislike for warm food, drinks or may suffer from the feeling of being alone and death.
• Hamamelis
  This remedy is used for bleeding from any incision or injury, particularly effective in cases of hemorrhoids, nosebleeds and busted blood vessels in the eye.
• Lachesis
  This homeopathic medication is generally used for profuse bleeding when the color of the blood is murky. This remedy is especially useful for red-headed persons those that are envious and disheartened.
• Millefolium
  This remedy is useful for internal as well as external injuries accompanied with considerable bleeding and weak blot clot formation.
• Phosphorus
  This is used for recurrent and profuse bleeding. This homeopathic remedy is most effective for persons who suffer from cold sweats and crave for alcoholic beverages. Such people may often have the feeling that clothing leads to suffocation of their throat.
• Secale
  This medication is especially used to cure the type of bleeding that deteriorates with heat and diminishes owing to cold.

Additional things you may do

Undertaking physical exercises on a regular basis will help to develop powerful muscles and this, in turn, will enable you to avoid problems of the joints. In fact, it is possible for the hemophilia patients to undertake majority of the physical exercises unharmed. However, such people should keep off from participating in any type of contact sports. In addition, seeking physical therapy possibly has a crucial part in lessening problems of the joints owing to repetitive bleeding in the affected areas. Your physical therapist may recommend you the following work-outs:

• Stretching
• Resistance training (like weight lifting)
• Movement exercises

However, it is important that people with hemophilia should not do things on their own, but work with their physicians and physical therapists to create a health regimen that suits them best. It is essential that this program should be followed for a minimum period of six to nine months in order to cure chronic joint inflammation as well as thwart acute bleeding.

Acupuncture

Before we discuss this topic, it needs to be mentioned that people suffering from hemophilia should not try acupuncture as it may enhance the hazards of bleeding. However, despite this, if they desire to try out acupuncture, they should essentially work with a qualified and certified acupuncturist experienced in handling hemophilia cases. In fact, it is always advisable that hemophilia patients should go for non-invasive acupuncture like laser acupuncture, as this will not augment the risk of bleeding.

Nourishment

Honestly speaking, thus far, no research has been undertaken to ascertain the connection between nourishment and hemophilia. Nevertheless, it is advisable that people with hemophilia should keep away from taking vitamin E supplements and fish oil, as these substances have been found to prolong the bleeding period by preventing any cohesion among the platelets. On the other hand, vitamin K has a crucial part in aiding usual blood clot formation and may be included in the diets of people having hemophilia. While more studies are needed in this regard, such patients may also benefit by taking vitamin K supplements. However, here is a word of caution - hemophilia patients should never ever take vitamin K supplements without consulting their physician.

Other beneficial herbs

• American Groundnut

Other Treatments that are helpful to Treat Bleeding in Hemophilia A and B

Desmopressin

Desmopressin is a synthetic drug which is a copy of a natural hormone. Desmopressin is not made from blood. Desmopressin is useful in treating people with mild or moderate hemophilia A. It is of no value for people with severe hemophilia A or with any type of hemophilia B.

It acts by releasing von Willebrand factor stored in the lining of the blood vessels. Von Willebrand factor is another protein which is important in blood clotting. One of its roles is to transport factor VIII in the bloodstream. Doctors think that by increasing von Willebrand factor levels, more factor VIII is brought to the site of damaged blood vessels.

Desmopressin can be taken in three different ways.

• It can be injected into a vein. Most often, the brand name for this kind of desmopressin is DDAVP.
• It can be injected under the skin. The brand name for this kind of desmopressin is often Octostim.
• It can be taken by nasal spray. The brand name of the nasal spray is often Octostim Spray.

Desmopressin is usually effective for mild and moderate hemophiliacs. However, different people respond to desmopressin in different ways. Therefore, a doctor needs to do tests to find out each individual's response to the drug. Ideally, these tests are done before any urgent need for the drug, such as surgery.

Since desmopressin acts by releasing von Willebrand factor stored in the body, you cannot 'go to the well' too often. A sufficient amount of time, usually 24 hours, must elapse between doses of desmopressin to allow the body to rebuild its stores.

In serious bleeds or major surgery, desmopressin alone may not be enough to control bleeding. In such a case, a person should also receive a concentrate of factor VIII. (See What are the blood products of choice for hemophilia A?)

Desmopressin can sometimes have some mild side effects. These are:

• facial flushing
• mild headache
• nausea and abdominal cramps.

Desmopressin can make the body retain water. Therefore, doctors recommend that after receiving desmopressin people drink only enough fluid to satisfy thirst.

If a person has a very bad headache or has not been able to pass water 24 hours after taking desmopressin, he / she should go to the hemophilia / bleeding disorder clinic or emergency room for help.

Cyklokapron and Amicar

Cyklokapron (tranexamic acid) and Amicar (aminocaproic acid) are useful in treating both hemophilia A and B.

Cyklokapron and Amicar are drugs that help to hold a clot in place once it has formed. They act by stopping the activity of an enzyme, called plasmin, which dissolves blood clots.

They do not help to actually form a clot. This means they can not be used instead of desmopressin or factor VIII or IX concentrate.

They can be used to hold a clot in place in mucous membranes such as:

• the inside of the mouth
• the inside of the nose
• inside the intestines (the gut)
• inside the uterus (the womb).

Cyklokapron and Amicar have proven very useful for people with hemophilia and for carriers who experience bleeding.
They are used:

• before dental work
• when a person has mouth, nose and minor intestinal bleeding
• for carriers with heavy, prolonged menstrual bleeding.

These drugs come in tablet form.

Cyklokapron and Amicar can sometimes have some mild side effects. These are:

• feeling sick to the stomach (nausea)
• feeling tired or sleepy
• feeling dizzy
• having loose bowel movements (diarrhea)
• having pain in the stomach.

These mild side effects go away when:

• a person stops taking the drugs or
• the doctor reduces the dosage.

New Gene Therapy Proves Promising as Hemophilia Treatment

Researchers at the UNC School of Medicine and the Medical College of Wisconsin found that a new kind of gene therapy led to a dramatic decline in bleeding events in dogs with naturally occurring hemophilia A, a serious and costly bleeding condition that affects about 50,000 people in the United States and millions more around the world.

Before the gene treatment, the animals experienced about five serious bleeding events a year. After receiving the novel gene therapy, though, they experienced substantially fewer bleeding events over three years, as reported in the journal Nature Communications.

“The promise and the hope for gene therapy is that people with hemophilia would be given a single therapeutic injection and then would express the protein they are missing for an extended period of time, ideally for years or even their entire lifetimes,” said Tim Nichols, MD, director of the Francis Owen Blood Research Laboratory at UNC and co-author of the paper. The hope is that after successful gene therapy, people with hemophilia would experience far fewer bleeding events because their blood would clot better.

People with hemophilia A lack the coagulation factor VIII in their blood plasma – the liquid in which red, white, and platelet cells are suspended.

“Bleeding events in hemophilia are severe, and without prompt factor VIII replacement, the disease can be crippling or fatal,” said Nichols, a professor of medicine and pathology. “The random and spontaneous nature of the bleeding is a major challenge for people with hemophilia and their families.”

In underdeveloped countries, people with hemophilia and many undiagnosed people typically die from bleeding in their late teens or early 20s. In developed countries, patients usually live fairly normal lives, as long as they receive preventive injections of recombinant protein therapy a few times a week. The disease requires life-long management that is not without health risks. The annual cost of medications alone is about $200,000 a year.

However, about 35 percent of people with hemophilia A develop an antibody response that blocks the factor VIII therapy. They require continuous infusions of various protein factors and they face a higher mortality rate. Also, the cost of treatment can easily rise to $2 million or more a year per patient.

Nichols and David Wilcox from the Medical College of Wisconsin figured out a potential way around the antibody response in dogs with naturally occurring hemophilia A.

Using a plasmapheresis machine and a blood-enrichment technique, the research team isolated specific platelet precursor cells from three dogs that have hemophilia A. The team then engineered those platelet precursor cells to incorporate a gene therapy vector that expresses factor VIII. The researchers put those engineered platelet precursors back into the dogs. As the cells proliferated and produced new platelets, more and more were found to express factor VIII.

Then, nature took over. Platelets naturally discharge their contents at sites of vascular injury and bleeding. In this experiment, the contents included factor VIII.

In the 2 1/2 years since the dogs received the gene therapy, researchers found that factor VIII was still being expressed in platelets that were coursing throughout the vascular systems of all three dogs. All three experienced much less bleeding. In the dog that expressed the most factor VIII in platelets, the bleeding was limited to just one serious event each year over the course of three years. And such bleeding events were easily treatable with current standard therapies.

“This has been very successful,” Nichols said. “And now we want to explore the possibility of moving it into human clinical trials for people with hemophilia A, similar to what Paul Monahan and Jude Samulski at UNC are currently doing for people with hemophilia B, which is a deficiency of factor IX.”

If approved, the platelet-targeted therapy would likely be restricted to patients who develop the antibody that stifles factor VIII therapy through normal injections. But as the gene therapy is refined, it could become a viable option for people with blood disorders who don’t have inhibitory antibodies.

This research was funded by the National Institutes of Health, the American Heart Association, the National Gene Vector Biorepository, and through gifts from the Children’s Hospital Foundation, the MACC Fund, and John B. and Judith Gardetto. The research team included scientists from the UNC School of Medicine, the Medical College of Wisconsin, the Blood Center of Wisconsin, Indiana University School of Medicine, the MACC Fund Research Center, and Hospital Xavier Arnozan in France.

"प्राचीन स्वास्थ्य दोहावली"

पानी में गुड डालिए, बीत जाए जब रात!
सुबह छानकर पीजिए, अच्छे हों हालात!!

धनिया की पत्ती मसल, बूंद नैन में डार!
दुखती अँखियां ठीक हों, पल लागे दो-चार!!


ऊर्जा मिलती है बहुत, पिएं गुनगुना नीर!
कब्ज खतम हो पेट की, मिट जाए हर पीर!!

प्रातः काल पानी पिएं, घूंट-घूंट कर आप!
बस दो-तीन गिलास है, हर औषधि का बाप!!

ठंडा पानी पियो मत, करता क्रूर प्रहार!
करे हाजमे का सदा, ये तो बंटाढार!!

भोजन करें धरती पर, अल्थी पल्थी मार!
चबा-चबा कर खाइए, वैद्य न झांकें द्वार!!


प्रातः काल फल रस लो, दुपहर लस्सी-छांस!
सदा रात में दूध पी, सभी रोग का नाश!!

दही उडद की दाल सँग, प्याज दूध के संग!
जो खाएं इक साथ में, जीवन हो बदरंग!!

प्रातः- दोपहर लीजिये, जब नियमित आहार!
तीस मिनट की नींद लो, रोग न आवें द्वार!!

भोजन करके रात में, घूमें कदम हजार!
डाक्टर, ओझा, वैद्य का, लुट जाए व्यापार !!


देश,भेष,मौसम यथा, हो जैसा परिवेश!
वैसा भोजन कीजिये, कहते सखा सुरेश!!

इन बातों को मान कर, जो करता उत्कर्ष!
जीवन में पग-पग मिले, उस प्राणी को हर्ष!!

घूट-घूट पानी पियो, रह तनाव से दूर!
एसिडिटी, या मोटापा, होवें चकनाचूर!!

अर्थराइज या हार्निया, अपेंडिक्स का त्रास!
पानी पीजै बैठकर, कभी न आवें पास!!

रक्तचाप बढने लगे, तब मत सोचो भाय!
सौगंध राम की खाइ के, तुरत छोड दो चाय!!


सुबह खाइये कुवंर-सा, दुपहर यथा नरेश!
भोजन लीजै रात में, जैसे रंक सुरेश!!

देर रात तक जागना, रोगों का जंजाल!
अपच,आंख के रोग सँग, तन भी रहे निढाल!!

टूथपेस्ट-ब्रश छोडकर, हर दिन दोनो जून!
दांत करें मजबूत यदि, करिएगा दातून!!

हल्दी तुरत लगाइए, अगर काट ले श्वान!
खतम करे ये जहर को, कह गए कवि सुजान!!


मिश्री, गुड, शहद, ये हैं गुण की खान!
पर सफेद शक्कर सखा, समझो जहर समान!!

चुंबक का उपयोग कर, ये है दवा सटीक!
हड्डी टूटी हो अगर, अल्प समय में ठीक!!

दर्द, घाव, फोडा, चुभन, सूजन, चोट पिराइ!
बीस मिनट चुंबक धरौ, पिरवा जाइ हेराइ!!

हँसना, रोना, छींकना, भूख, प्यास या प्यार!
क्रोध, जम्हाई रोकना, समझो बंटाढार!!


सत्तर रोगों कोे करे, चूना हमसे दूर!
दूर करे ये बाझपन, सुस्ती अपच हुजूर!!

यदि सरसों के तेल में, पग नाखून डुबाय!
खुजली, लाली, जलन सब, नैनों से गुमि जाय!!

आलू का रस अरु शहद, हल्दी पीस लगाव!
अल्प समय में ठीक हों, जलन, फँफोले, घाव!!

भोजन करके जोहिए, केवल घंटा डेढ!
पानी इसके बाद पी, ये औषधि का पेड!!

जो भोजन के साथ ही, पीता रहता नीर!
रोग एक सौ तीन हों, फुट जाए तकदीर!!


पानी करके गुनगुना, मेथी देव भिगाय!
सुबह चबाकर नीर पी, रक्तचाप सुधराय!!

मूंगफली, तिल, नारियल, घी सरसों का तेल!
यही खाइए नहीं तो, हार्ट समझिए फेल!!

पहला स्थान सेंधा नमक, काला नमक सु जान!
श्वेत नमक है सागरी,  ये है जहर समान!!

तेल वनस्पति खाइके, चर्बी लियो बढाइ!
घेरा कोलेस्टरॉल तो, आज रहे चिल्लाइ!!

अल्यूमिन के पात्र का, करता है जो उपयोग!
आमंत्रित करता सदा, वह अडतालीस रोग!!


फल या मीठा खाइके, तुरत न पीजै नीर!
ये सब छोटी आंत में, बनते विषधर तीर!!

चोकर खाने से सदा, बढती तन की शक्ति!
गेहूँ मोटा पीसिए, दिल में बढे विरक्ति!!

नींबू पानी का सदा, करता जो उपयोग!
पास नहीं आते कभी, यकृति-आंत के रोग!!

दूषित पानी जो पिए, बिगडे उसका पेट!
ऐसे जल को समझिए, सौ रोगों का गेट!!

रोज मुलहठी चूसिए, कफ बाहर आ जाय!
बने सुरीला कंठ भी, सबको लगत सुहाय!!


भोजन करके खाइए, सौंफ, और गुड, पान!
पत्थर भी पच जायगा, जानै सकल जहान!!

लौकी का रस पीजिए, चोकर युक्त पिसान!
तुलसी, गुड, सेंधा नमक, हृदय रोग निदान!!

हृदय रोग, खांसी और आंव करें बदनाम!
दो अनार खाएं सदा, बनते बिगडे काम!!

चैत्र माह में नीम की, पत्ती हर दिन खावे !
ज्वर, डेंगू या मलेरिया, बारह मील भगावे !!

सौ वर्षों तक वह जिए, लेत नाक से सांस!
अल्पकाल जीवें, करें, मुंह से श्वासोच्छ्वास!!

मूली खाओ हर दिवस, करे रोग का नाश!
गैस और पाईल्स का, मिट जाए संत्रास!!


जब भी लघु शंका करें, खडे रहे यदि यार!
इससे हड्डी रीढ की, होती है बेकार!!

सितम, गर्म जल से कभी, करिये मत स्नान!
घट जाता है आत्मबल, नैनन को नुकसान!!

हृदय रोग से आपको, बचना है श्रीमान!
सुरा, चाय या कोल्ड्रिंक, का मत करिए पान!!

अगर नहावें गरम जल, तन-मन हो कमजोर!
नयन ज्योति कमजोर हो, शक्ति घटे चहुंओर!!

तुलसी का पत्ता करें, यदि हरदम उपयोग!
मिट जाते हर उम्र में, तन के सारे रोग!!


मछली के संग दूध या, दूध-चाय, नमकीन!
चर्म रोग के साथ में, रोग बुलाते तीन!!

बर्गर, गुटखा, सुरा अरु,  कोक सुअर का मांस!
जो हरदम सेवन करे, बने गले का फाँस!!

संस्कृत के बारे में कुछ रोचक तथ्य-

=================
संस्कृत के बारे में ये 20 तथ्य जान कर आपको भारतीय होने पर गर्व होगा  |
आज हम आपको संस्कृत के बारे में कुछ ऐसे तथ्य बता रहे हैं, जो किसी भी भारतीय का सर गर्व से ऊंचा कर देंगे

1. संस्कृत को सभी भाषाओं की जननी माना जाता है।

2. संस्कृत उत्तराखंड की आधिकारिक भाषा है।

3. अरब लोगो के हस्तक्षेप से पहले संस्कृत भारत की राष्ट्रीय भाषा थी।

4. NASA के मुताबिक, संस्कृत धरती पर बोली जाने वाली सबसे स्पष्ट भाषा है।

5. संस्कृत में दुनिया की किसी भी भाषा से ज्यादा शब्द है वर्तमान में संस्कृत के शब्दकोष में 102 अरब 78 करोड़ 50 लाख शब्द है।

6. संस्कृत किसी भी विषय के लिए एक अद्भुत खजाना है। जैसे हाथी के लिए ही संस्कृत में 100 से ज्यादा शब्द है।

7. NASA के पास संस्कृत में ताड़पत्रो पर लिखी 60,000 पांडुलिपियां है जिन पर नासा रिसर्च कर रहा है।

8. फ़ोर्ब्स मैगज़ीन ने जुलाई,1987 में संस्कृत को Computer Software के लिए सबसे बेहतर भाषा माना था।

9. किसी और भाषा के मुकाबले संस्कृत में सबसे कम शब्दो में वाक्य पूरा हो जाता है।

10. संस्कृत दुनिया की अकेली ऐसी भाषा है जिसे बोलने में जीभ की सभी मांसपेशियो का इस्तेमाल होता है।

11. अमेरिकन हिंदु युनिवर्सिटी के अनुसार संस्कृत में बात करने वाला मनुष्य बीपी, मधुमेह, कोलेस्ट्रॉल आदि रोग से मुक्त हो जाएगा. संस्कृत में बात करने से मानव शरीरका तंत्रिका तंत्र सक्रिय रहता है जिससे कि व्यक्ति का शरीर सकारात्मक आवेश(PositiveCharges) के साथ सक्रिय हो जाता है।

12. संस्कृत स्पीच थेरेपी में भी मददगार है यह एकाग्रता को बढ़ाती है।

13. कर्नाटक के मुत्तुर गांव के लोग केवल संस्कृत में ही बात करते है।

14. सुधर्मा संस्कृत का पहला अखबार था, जो 1970 में शुरू हुआ था। आज भी इसका ऑनलाइन संस्करण उपलब्ध है।

15. जर्मनी में बड़ी संख्या में संस्कृतभाषियो की मांग है। जर्मनी की 14 विश्वविद्यालयों में संस्कृत पढ़ाई जाती है।

16. नासा के वैज्ञानिकों के अनुसार जब वो अंतरिक्ष यात्रियों को मैसेज भेजते थे तो उनके वाक्य उलट हो जाते थे. इस वजह से मैसेज का अर्थ ही बदल जाता था. उन्होंले कई भाषाओं का प्रयोग किया लेकिन हर बार यही समस्या आई | आखिर में उन्होंने संस्कृत में मैसेज भेजा क्योंकि संस्कृत के वाक्य उल्टे हो जाने पर भी अपना अर्थ नही बदलते हैं।

जैसे--

अहम् विद्यालयं गच्छामि |
विद्यालयं गच्छामि अहम्।
गच्छामि अहम् विद्यालयं ।

उक्त तीनों के अर्थ में कोई अंतर नहीं है।

17. आपको जानकर हैरानी होगी कि Computer द्वारा गणित के सवालों को हल करने वाली विधि यानि Algorithms संस्कृत में बने है ना कि अंग्रेजी में।

18. नासा के वैज्ञानिकों द्वारा बनाए जा रहे 6th और 7th जेनरेशन(पीढी़) Super Computers संस्कृतभाषा पर आधारित होंगे जो 2034 तक बनकर तैयार हो जाएंगे।

19. संस्कृत सीखने से दिमाग तेज हो जाता है और याद करने की शक्ति बढ़ जाती है। इसलिए London और Ireland के कई स्कूलो में संस्कृत को अनिवार्य विषय बना दिया है।

20. इस समय दुनिया के 17 से ज्यादा देशों के कम से कम एक विश्वविद्यालय में तकनीकी शिक्षा के पाठ्यक्रम में संस्कृत पढ़ाई जाती है।

संस्कृत के बारे में ये 20 तथ्य जान कर आपको भारतीय होने पर गर्व होगा।

Hemophilia Gene Therapy

Gene therapy for the X-linked bleeding disorder hemophilia B—factor IX (FIX) deficiency—by means of in vivo gene transfer with adeno-associated viral (AAV) vectors has been in clinical trials for the past 16 years, cycling between partial successes in the clinic and further development in the laboratory. At the recent World Congress of the International Society on Thrombosis and Haemostasis (Toronto, Canada, June 2015), Paul Monahan and colleagues presented data from a patient who has achieved FIX levels of 20–25% that have been sustained for more than 6 months since undergoing hepatic gene transfer with an AAV8 vector (administered via peripheral vein). This result, representing another milestone in gene therapy for hemophilia, was in part accomplished by incorporating a missense mutation into a codon-optimized FIX sequence, which improves FIX enzymatic activity by 5- to 10-fold. However, similarly treated patients lost therapeutic expression because of immune responses to virally transduced hepatocytes or for other, yet-to-be-determined reasons.

In the past decade, gene therapy for hemophilia B has focused on expression and secretion of FIX by hepatocytes into the circulation. Sustained correction from severe to mild hemophilia (>5% of normal coagulation activity) using an AAV serotype 8 vector has been documented in recent years. Further improvements so as to sustain levels of >10% would essentially represent a cure for most patients, preventing spontaneous bleeds and limiting the need for intravenous factor infusions to surgery and treatment of severe trauma. The ”Padua” mutation was discovered when analyzing a case of X-linked juvenile thrombophilia, and has since been rigorously tested for improved gene therapy in murine and canine models of hemophilia B. For the clinical trial sponsored by Baxalta and conducted by Monahan and colleagues at the University of North Carolina–Chapel Hill, an FIX expression cassette was incorporated into a self-complementary AAV (scAAV), a vector system initially developed by McCarty and Samulski to eliminate the need for second-strand synthesis, which limits traditional AAV vectors. Seven patients have been treated in the trial thus far, and the results vary widely.

It has been known for 10 years that the immune system may limit the duration of therapeutic gene expression from AAV vectors in the human liver. The discovery of a hepatotoxic CD8⁺ T-cell response against AAV capsid was surprising at the time because none of the animal models had shown anything similar. Several articles in Molecular Therapy have since uncovered differences between murine and human, and even human and nonhuman primate, T-cell responses to capsid. More recently, a murine model was developed that mimics transaminitis and loss of FIX expression after ex vivo expansion followed by adoptive transfer of capsid-specific CD8⁺ T cells. At the highest vector dose in the current trial by Monahan et al. (3 × 10¹² vector genomes/kg), both patients showed even higher levels of expression than those mentioned above (up to >50% of normal) but subsequently lost expression concomitant with transaminitis and a T-cell response to capsid. It remains remarkable that these responses may emerge two months after vector administration. No immune response against FIX (or the Padua variant) was found. In efforts to counter the destructive T cells, elevation of liver enzyme levels has previously been established as a biomarker that warrants initiation of immune suppression, and the steroid drug prednisone has been successfully applied to stop the T-cell response to AAV8 in its tracks and preserve FIX expression.

Although the same strategy was adopted in the trial by Monahan et al., efforts to preserve gene expression upon onset of transaminitis were unsuccessful. One drawback to this approach is that drug administration must be initiated very soon after the first signs of hepatotoxicity. Additionally, transaminitis may not be a sufficiently sensitive biomarker, and steroid drugs may not be effective against T-cell responses in all patients. Hence, the field continues to wrestle with the question of whether a prophylactic immunosuppression protocol should be incorporated into hepatic AAV gene transfer, and how such a regimen should be designed. Preclinical studies suggest a requirement for innate immune sensing of the AAV genome by Toll-like receptor 9 (TLR9) for CD8⁺ T-cell activation. Development of vectors devoid of TLR9-activating CpG motifs has been proposed. Using scAAV vectors may, on the one hand, increase or accelerate responses because of stronger TLR9 signaling, which, on the other hand, could be an advantage by providing a more defined target for immune suppression. No changes in liver enzymes or capsid-specific T cells were detected at a mid-dose of 1 × 10¹² vector genomes/kg, reinforcing the conclusion that the T-cell response is vector dose–dependent. However, differences in vector production, purification, design (such as promoter), and measurement of titers complicate a direct comparison between trials. Interestingly, the three patients treated with the mid-dose experienced very diverse outcomes.

As mentioned, one patient continues to express at curative levels of >20%, whereas the others showed therapeutic levels initially but then spontaneously lost expression in the absence of any evidence for an immune response. Although minor changes in persistence of gene transfer or expression may have been amplified by the highly active Padua mutation, this observation remains unsettling because it adds another layer of complexity. Hence, AAV gene transfer to the human liver is caught somewhere between a cure, cellular immune responses, and additional factors that have yet to be determined.

Roland W. Herzog

Home Remedies for Indigestion

Also called as dyspepsia, indigestion can be quite a troublesome medical condition. Indigestion usually occurs when an issue crops up with the regular secretion of stomach acids (aka digestive juices) in the stomach. And most of the times, this happens due to an improper diet or unhealthy eating habits. Indigestion needs to be taken care of promptly in order to avoid much more serious conditions in the future. And the exact cause of the condition would have to be known in order to follow the right treatment. Given below are some of the common causes and symptoms of indigestion, along with a few essential home remedies that can help treat the condition effectively.

Causes for Indigestion 

Indigestion can be caused by any condition that disturbs the normal secretion of the stomach acids. As such, some of the common causes for indigestion include overeating, eating quickly without chewing the food properly, eating fatty, fried, greasy, oily and spicy foods, smoking, alcohol consumption, excess intake of caffeinated products, anxiety, constipation, stomach ulcer, gastritis, intestinal blockage, gallstones, celiac disease, pancreatitis, peptic ulcers and intestinal ischemia etc.

  

Symptoms of Indigestion

Indigestion can cause quite a few bothersome symptoms and side effects in individuals. These include bloating, burning sensation in the stomach and abdominal regions, excess gas formation, abdominal pain, early fullness during meals, nausea, vomiting and belching etc.

Home Remedies for Indigestion

Indigestion can be easily treated with the help of certain home remedies, the more common of which, are given below.

Cinnamon

Drinking cinnamon tea daily can take care of indigestion and its symptoms like gas formation and bloating. Add cinnamon powder (1/2 teaspoon) to water (1 cup) and boil the mixture nicely for about 15 minutes. Let the mixture cool down to room temperature. Strain it and drink it to get instant relief from the pain, discomfort and burning sensation caused by indigestion.

Baking Soda

Excess stomach acids in the digestive tract can cause indigestion. Baking soda would neutralize the stomach acids and reduce the gas, cramps and bloating caused by indigestion. Add baking soda (1 teaspoon) to lukewarm water (1 glass) and stir nicely till the baking soda dissolves completely. Drink this solution to get instant relief from indigestion and its symptoms. 

Ginger

Chewing on some raw ginger slices after meals can get rid of the uncomfortable feeling of fullness nausea. It can also effectively cure the stomach ache, bloating, gas and cramps caused by indigestion as well. Peel a piece of ginger and place it in between your teeth at the back of your mouth. Bite down hard on the ginger piece and suck on its juice slowly. Doing so would provide immense relief from indigestion. Alternatively, grind some ginger pieces and add the resultant paste to hot water (1 cup). Let the mixture steep for 5 minutes or so. Strain the concoction and drink it to get rid of indigestion quickly.

Orange

Low levels of stomach acids in the digestive tract can also cause indigestion (there would not be enough acid to digest the food that is consumed). Orange contains ascorbic acid and citric acids, both of which would increase the levels of the stomach acids in the stomach, thereby quickening the digestion process and treating indigestion in addition to preventing recurrences. Note: Pineapple also works well for indigestion, and can be used as a substitute for orange.

Apple

Apple contains high amounts of fiber that can improve the digestion process and effectively clear out intestinal blockages. This would in turn, prompt the smooth flow of food through the digestive tract, thereby treating indigestion and its symptoms very quickly. Eat an apple after meals every day for the same purpose. Note: Try eating the apple with the peel, for the peel is a rich source of fiber.

Grapefruit Peel

The peel of a grapefruit is enriched with nutrients that can stimulate the production of digestive acids in the stomach and promote the smooth flow of food through the digestive tract. Peel a grapefruit and grind the peel to form a coarse powder.

Sundry this powder for about an hour or so. Store the powder in a bottle and consume a teaspoon of it whenever you suffer from indigestion. The powder would start working almost immediately, and would offer prompt relief from indigestion and its symptoms like stomach ache and cramps etc.

Water

Drinking a glass of lukewarm water whenever you feel indigestion setting in, would help get rid of the condition promptly. Water would dilute the excess stomach acids, thereby providing immense relief from the pain, burning sensation and bloating caused by indigestion. Opt to drink a glass of lukewarm water at regular intervals throughout the day. You can also add some ginger and lime juice (a few drops each) to the water along with honey (1 teaspoon) before drinking it.